The CD49b antigen is a transmembrane glycoprotein of 150 kDa also known as the α-2 integrin and as platelet GPIa. CD49b non-covalently pairs with the β-1 integrin (CD29, GPIIa) to form the VLA-2 (very late activation antigen) complex. CD49b complexed to CD29 is involved in cell adhesion to collagen. It is expressed by platelets, activated T lymphocytes and thymocytes.
Технические характеристики
| Target Species | Human |
| Specificity | CD49b |
| Other Names | CD49b, gpIa, Integrin alpha 2 chain, Integrin alpha2-chain, platelet gpla, VLA-2, VLA-alpha 2-chain |
| Fluorochrome | UNLB |
| Regulatory Status | RUO |
| Size | 0.2 mg |
| Format | Freeze-dried |
| Clone | Gi9 |
| Isotype | IgG1 Mouse |
| Clone Description | The Gi9 antibody reacts with the molecule carrying the Br(a) as well as the Br(b) alloantigen. This antibody inhibits the adhesion of platelets to collagen. It detects human alloantibodies (anti-Br a,b) against VLA-2 by MAIPA assay. Gi9 was used as a CD49b reference monoclonal antibody during the HLDA 6. Gi9 reacts with platelets and weakly with monocytes. It also stains most adherent cell lines and T lymphocytes in culture. |
