The CD103 antigen was originally described as the human mucosal antigen 1 (HML-1) and was subsequently proved to be the integrin αE subunit. CD103 is composed of a 150 kDa chain associated with a 25 kDa chain by a disulfide bond. It is expressed as a heterodimer in association with the integrin β7 chain. CD103 is expressed on mucosa-associated T lymphocytes and activated cells. This human intra-epithelial lymphocyte marker is expressed in very few resting peripheral blood lymphocytes. αEβ7 binds to E-cadherin on epithelial cells. Activation and TGFβ-1 induce CD103 expression.
Технические характеристики
| Target Species | Human |
| Specificity | CD103 |
| Other Names | CD103, HML-1, Integrin alpha E subunit, Integrin alphaE-chain |
| Fluorochrome | UNLB |
| Regulatory Status | RUO |
| Size | 0.2 mg |
| Format | Freeze-dried |
| Clone | 2G5 |
| Isotype | IgG2a Mouse |
| Clone Description | The 2G5 antibody stains a few bone marrow cells and, rarely, peripheral blood lymphocytes. |
| Cross Reactivity | Indian Rhesus, Sooty Mangabey |
