Zap-70, a Syk family protein tyrosine kinase expressed in T and NK cells, plays a critical role in mediating T cell activation in response to T cell receptor (TCR) engagement. Following TCR engagement, Zap-70 is rapidly phosphorylated on several tyrosine residues, presumably by two mechanisms: autophosphorylation and transphosphorylation by the Src family tyrosine kinase, Lck. Tyrosine phosphorylation of Zap-70 correlates with its increased kinase activity and downstream signaling events.
Технические характеристики
| Target Species | Human |
| Specificity | ZAP-70 |
| Fluorochrome | UNLB |
| Regulatory Status | RUO |
| Size | 50 Tests |
| Format | Liquid |
| Clone | SBZAP |
| Isotype | IgG1 Mouse |
| Clone Description | The monoclonal antibody SBZAP was generated against a KLH-peptide sequence corresponding to the human ZAP-70 amino acid residues 280-309. |
