The HLA (Human Leucocyte Antigen) system is the name given to the major histocompatibility complex (MHC) in man. The MHC complex is located on the short arm of the chromosome 6 and encodes three groups of molecules designated MHC class I, class II and class III. Coded by 5 loci (DM, DO, DP, DQ and DR) of the D locus, HLA class II molecules are also called HLA-DM, HLA-DO, HLA-DP, HLA-DQ and HLA-DR antigens. The HLA class II molecules like class I molecules, are composed of non-covalently associated α/β heteterodimers. On HLA class II, both heavy (α) and light (β) chain with a molecular weight of 31-33 kDa and 26-29 kDa respectively span the cell membrane. The two immunoglobulin-like domains proximal to the cell membrane (α2 and β2) support the two polymorphic amino-terminal domains (α1 and β1) distal to the membrane which constitute a part of the «antigen presenting site». HLA class II molecules are involved in the regulation of immune response whose expression is limited to antigen presenting cells, i.e. B lymphocytes, monocytes / macrophages, dendritic and Langerhans cells of the skin.
Технические характеристики
| Target Species | Human |
| Specificity | HLA-DQ |
| Other Names | HLA Class II, HLA-DQ |
| Fluorochrome | UNLB |
| Regulatory Status | RUO |
| Size | 0.2 mg |
| Format | Freeze-dried |
| Clone | SPVL3 |
| Isotype | IgG2a Mouse |
| Clone Description | The monoclonal antibody SPVL3 recognizes a monomorphic determinant of human class II HLA-DQ molecules The SPVL3 antibody has been used in studies of inhibition of antigen-specific cytolytic T cell clones. |
