The CD40 antigen is a glycosylated phosphoprotein. It is a member of the Tumor Necrosis Factor Receptor (TNFR) superfamily and contains four cysteine-rich repeats. Its molecular weight is about 44-48 kDa. CD40 antigen is present on all mature B lymphocytes, but not on plasma cells. It is strongly expressed by interdigitating cells, some epithelial cells, follicular dendritic cells, and fibroblasts and macrophages. CD40 binds to CD154 (CD40 ligand) on T cells, resulting in B cell growth and differentiation.
Технические характеристики
| Target Species | Human |
| Specificity | CD40 |
| Other Names | Bp50, CD40, TNF Receptor 5 |
| Fluorochrome | PC5.5 |
| Regulatory Status | ASR |
| Size | 0.5 mL |
| Format | Liquid |
| Flow Product Line | IOTest |
| Clone | MAB89 |
| Isotype | IgG1 Mouse |
| Clone Description | Co-culture with MAB89 and IL-4 leads to long term B cell proliferation. |
