In humans, there are two A-type cyclins – an embryonic-specific cyclin A1 and a somatic cyclin A2. Cyclin A1 is only expressed in meiosis and very early embryos, whereas cyclin A2 is present in proliferating somatic cells. Cyclin A2 is a 48 kDa protein composed of 432 amino-acids. Cyclins control the activation of cyclin dependent kinases (CDKs) by associating with them to form a cyclin-CDK complex able to phosphorylate selected proteins and to induce downstream processes. The cyclin A2-CDK2 complex initiates DNA replication and is required for S phase progression. For passage through G2 to M phase, cyclin A2 complexes to the CDK1 (also called CDC2). Cyclin A2 is degraded via the ubiquitin-dependant proteolysis pathway in the early phases of mitosis.
Технические характеристики
| Target Species | Human |
| Specificity | Cyclin A2 |
| Fluorochrome | PE |
| Regulatory Status | ASR |
| Size | 1 mL |
| Format | Liquid |
| Flow Product Line | IOTest |
| Clone | 11B2G3 |
| Isotype | IgG1 Mouse |
