The anti-IgE mAb binds to circulating IgE as well as to IgE antibodies bound to the low affinity receptor FcεRII (expressed mainly on eosinophils, B lymphocytes), or to the high affinity receptor FcεRI (expressed on mast cells, basophils, monocytes and monocytes-derived cells). The anti-IgE antibody induces the histamine release from basophils. However, it is known in the literature information that basophils from 10% to 20% of donors completely fail to release histamine in response to anti-IgE, designated anti-IgE «non releasers».
Технические характеристики
| Target Species | Human |
| Specificity | IgE (Dε2) |
| Fluorochrome | UNLB |
| Regulatory Status | ASR |
| Size | 0.2 mg |
| Format | Freeze-dried |
| Clone | E124.2.8 |
| Isotype | IgG1 Mouse |
| Clone Description | The E124.2.8 monoclonal antibody binds specifically to the Dε2 constant domain of human Immunoglobulin E (IgE) (Dε2 is the heat labile region of IgE). |
