Helios belongs to the Ikaros transcription factor family. Members of this family are DNA binding proteins containing two-zinc finger N terminal domains and protein binding domain. Helios expression is restricted to the T lymphocytes lineage. Helios is suggested to play an important role in CD4+CD25+FoxP3+ regulatory cells. It has been shown that Helios up-regulates the expression of FoxP3 expression by binding to the FoxP3 promoter. Helios is a highly conserved transcription factor that has 97% sequence homology between human and mice. *Alexa Fluor and Pacific Blue are registered trademarks of Molecular Probes, Inc.
Технические характеристики
| Target Species | Human |
| Specificity | Helios |
| Fluorochrome | Pacific Blue* |
| Regulatory Status | RUO |
| Size | 50 Tests |
| Format | Liquid |
| Flow Product Line | IOTest |
| Clone | 22F6 |
| Isotype | IgG Hamster |
| Clone Description | The clone 22F6 reacts with human and mouse Helios. |
