The CD95 (Fas or APO-1) antigen is a 40-50 kDa transmembrane glycoprotein. It belongs to the Tumor Necrosis Factor (TNF) superfamily and contains three cysteine-rich repeats. This cell surface molecule mediates apoptosis (programmed cell death). CD95 antigen is expressed on a substantial proportion of peripheral blood CD4+ lymphocytes, CD8+ lymphocytes and B lymphocytes but on a minor proportion of NK cells. It is not found on platelets or erythrocytes, but is expressed variably on granulocytes and monocytes. CD95 is strongly up-regulated on activated T cells, B cells, NK cells and thymocytes. Moreover, it is widely expressed on cell lines of T, B, NK and myeloid lineages. Most other tissues express CD95.
Технические характеристики
| Target Species | Human |
| Specificity | CD95 |
| Other Names | APO-1, CD95, Fas, TNFRSF6 |
| Fluorochrome | UNLB |
| Regulatory Status | RUO |
| Size | 0 mg |
| Format | Liquid |
| Clone | CH11 |
| Isotype | IgM Mouse |
| Clone Description | The CH11 antibody in vitro induces apoptosis in some CD95 expressing cell lines. |
