The CD80 antigen (B7, BB1) is a highly glycosylated single-chain protein. Its extracellular domain consists of two Ig-like domains. This 60 kDa molecule shares with CD86 the capability to be the ligand for two structurally similar molecules expressed on T lymphocytes, CD28 and CD152 (CTLA-4). CD80 antigen is expressed on in vitro activated B lymphocytes after 24h stimulation and at maximal level 48-72h post activation. It is not expressed on the majority of resting B cells from peripheral blood but identifies a subpopulation of B cells that has been previously activated. The antigen is also expressed by HTLV-1 transformed T cells and activated monocytes. CD80 binding provides co-stimulatory signals for T cell activation.
Технические характеристики
| Target Species | Human |
| Specificity | CD80 |
| Other Names | B7, B7-1, BB1, CD80 |
| Fluorochrome | FITC |
| Regulatory Status | ASR |
| Size | 2 mL |
| Format | Liquid |
| Flow Product Line | IOTest |
| Clone | MAB104 |
| Isotype | IgG1 Mouse |
| Clone Description | The MAB104 monoclonal antibody reacts with in vitro activated B lymphocytes, some B cell lines, and weakly with a small proportion of non-activated B cells. This antibody also reacts with activated T cells but not with peripheral monocytes and T cells. |
