The CD8 antigen is a disulfide-linked dimer, which exists either as a CD8α homodimer or as a CD8α/β heterodimer. CD8α is required for surface expression of CD8β. The molecular weight of each monomer of α or β is approximately 32-34 kDa. CD8 binds to a non-polymorphic domain (α3 domain) of MHC Class I molecules. CD8 is expressed on a subset of human peripheral blood T lymphocytes. A subset of NK cells possess the CD8 antigen but show low to medium density of expression. CD8α homodimer is expressed by NK cells and γ/δ+ T cells. CD8 is also present on most thymocytes where it is frequently co-expressed with CD4, and on a subpopulation of bone marrow cells. The CD8 molecule acts with the T Cell Receptor (TCR) as a coreceptor for MHC class I restricted antigen recognition. CD8 is widely used as a marker of cytotoxic T lymphocytes.
Технические характеристики
| Target Species | Human |
| Specificity | CD8 |
| Other Names | CD8, T8 antigen |
| Fluorochrome | FITC |
| Regulatory Status | IVD, CE, Japan IVD |
| Size | 100 Tests |
| Format | Freeze-dried |
| Flow Product Line | coulter clone |
| Clone | SFCI21Thy2D3 |
| Isotype | IgG1 Mouse |
| Clone Description | SFCI21Thy2D3 monoclonal antibody recognizes the α chain of the CD8 molecule. |
| Cross Reactivity | Common Marmoset |