The CD7 antigen is a membrane-embedded glycoprotein with a molecular weight of 40 kDa. It is expressed at an early stage of T lineage ontogeny, during the extrathymic prothymocytic formation. CD7 expression persists throughout T lymphocytes differentiation defining CD7 as a pan-T marker. It is also expressed on thymocytes, on the majority of resting T lymphocytes, and Natural Killer cells (NK), and on a subset of pre-B lymphocytes and B lymphocytes from foetal bone marrow. CD7 expression is also detected on pluripotent hematopoietic stem cells. Mature B-lymphocytes, cells from erythroid, myeloid and megacaryocytic lineage do not express the CD7 molecule. The CD7 molecule is involved in T lymphocytes activation. Its expression may be quantitatively up-regulated on stimulated T lymphocytes.
Технические характеристики
| Target Species | Human |
| Specificity | CD7 |
| Other Names | CD7, gp40, T cell leukemia antigen |
| Fluorochrome | RD1 |
| Regulatory Status | ASR, Japan IVD |
| Size | 0.5 mL |
| Format | Liquid |
| Flow Product Line | coulter clone |
| Clone | 3A1E-12H7 |
| Isotype | IgG2b Mouse |
| Clone Description | 3A1E-12H7 (ref. 6T-CD7.4) was used as a CD7 reference monoclonal antibody during HLDA 6. |
