The CD66 antigens were originally described as granulocyte-specific activation antigens, related to the carcino-embryonic antigen (CEA) previously described on colon cancer cells. The CEA/CD66 gene group belongs to the immunoglobulin (Ig) gene superfamily. Among the CD66 cluster, CD66b (also known as CGM6) is a glycosyl-phosphatidylinositol (GPI)-anchored glycoprotein of 95-100 kDa. CD66b is thought to play a role in the regulation of the adhesive activity of CD11/CD18 via signal transduction in neutrophils. It is strongly expressed by myelocytes, metamyelocytes, neutrophils and polymorphonuclear neutrophils. CD66b is weakly expressed by promyelocytes.
Технические характеристики
| Target Species | Human |
| Specificity | CD66b |
| Other Names | CD66b, CEA family, CGM6, NCA-95 |
| Fluorochrome | APC-Alexa Fluor* 750 |
| Regulatory Status | ASR |
| Size | 0.5 mL |
| Format | Liquid |
| Flow Product Line | IOTest |
| Clone | 80H3 |
| Isotype | IgG1 Mouse |
| Clone Description | The 80H3 antibody does not react with peripheral lymphocytes and monocytes. |
