The CD62P antigen (P-selectin/GMP-140/PADGEM) is a member of the selectin family. Like other selectins (CD62E and CD62L), CD62P contains an amino terminal lectin-like domain, followed by an EGF domain, nine short consensus repeats (SCR), a transmembrane domain and a short cytoplasmic domain. CD62P (140 kDa) is present in megakaryocytes, in Weibel-Palade bodies of endothelial cells and in α-granules of platelets. CD62P is translocated to the surface membrane upon in vitro and in vivo activation. CD62P is involved in the interaction between activated platelets and with monocytes and neutrophils.
Технические характеристики
| Target Species | Human |
| Specificity | CD62P |
| Other Names | CD62P, GMP140, granule membrane protein-140, LECAM-3, PADGEM, P-selectin |
| Fluorochrome | PE |
| Regulatory Status | ASR |
| Size | 2 mL |
| Format | Liquid |
| Flow Product Line | IOTest |
| Clone | CLBThromb/6 |
| Isotype | IgG1 Mouse |
| Clone Description | The CLB-Thromb/6 antibody recognizes the boundary region between the lectin and EGF-like domains, which is preserved after platelet fixation. It inhibits platelet adhesion to eosinophils in cell adhesion assays. |
