CD58 is a glycoprotein of 65-70 kDa, either transmembrane or glycosylphosphatidylinositol (GPI)-anchored. CD58 was first described as the lymphocyte-function associated antigen 3 (LFA-3). LFA-3 was further shown to interact with CD2 suggesting an important role in various immunological responses via T-cell adhesion and activation. CD58 mediates adhesion between killer and target cells, antigen presenting cells and T cells. This antigen is widely expressed on leucocytes, erythrocytes and endothelial cells.
Технические характеристики
| Target Species | Human |
| Specificity | CD58 |
| Other Names | CD58, LFA-3, lymphocyte function associated antigen-3 |
| Fluorochrome | APC |
| Regulatory Status | ASR |
| Size | 1 mL |
| Format | Liquid |
| Flow Product Line | IOTest |
| Clone | AICD58 |
| Isotype | IgG2a Mouse |
| Clone Description | The AICD58 antibody is a blocking antibody in LFA-3 mediated adhesion. This antibody was used as a CD58 reference mAb during HLDA 6. |
