CD49d is the integrin α4 chain that non-covalently pairs with CD29 (β1 chain) to form the very late activation antigen 4 (VLA-4), or with the integrin β7 chain. CD49d is a transmembrane glycoprotein of 145 kDa devoid of disulfide bond. Complexed to β1 or β7 integrins, CD49d is not only involved in cell adhesion to fibronectin and vascular cell adhesion molecule 1 (VCAM-1), but also in intercellular leucocyte interactions. It is expressed by monocytes, lymphocytes, eosinophils, thymocytes and Langerhans cells.
Технические характеристики
| Target Species | Human |
| Specificity | CD49d |
| Other Names | CD49d, Integrin alpha 4 chain, Integrin α4-chain, VLA-4, VLA-alpha4-chain |
| Fluorochrome | FITC |
| Regulatory Status | ASR |
| Size | 2 mL |
| Format | Liquid |
| Flow Product Line | IOTest |
| Clone | HP2/1 |
| Isotype | IgG1 Mouse |
| Clone Description | The HP2/1 antibody blocks the interaction of VLA-4 with VCAM-1. HP2/1 was used as a CD49d reference monoclonal antibody during the HLDA 6. |
| Cross Reactivity | Indian Rhesus, Bovine, Ovine, Caprine, Equine, Canine, Feline, Mink, Llama, Rabbit, Carp |
