The CD42b antigen (GPIbα) is a membrane glycoprotein of 135 kDa, that forms a disulfide linked 160 kDa membrane protein with the CD42c (GP1bβ) known as GP1b. GP1b forms a noncovalent complex with GPIX (CD42a) and GPV (CD42d). This antigen is found on platelets and megakaryocytes. It has also been reported on vascular and tonsillar endothelial cells. The CD42a-d complex is the receptor for von Willebrand»s factor and is known as von Willebrand»s factor-dependent adhesion receptor.
Технические характеристики
| Target Species | Human |
| Specificity | CD42b |
| Other Names | CD42b, glycoprotein GPIb-a, gpIb, GPIb-a, platelet glycoprotein GPIb-a |
| Fluorochrome | UNLB |
| Regulatory Status | RUO |
| Size | 0.2 mg |
| Format | Freeze-dried |
| Clone | SZ2 |
| Isotype | IgG1 Mouse |
| Clone Description | The SZ2 monoclonal antibody prevents the ristocetin-dependent binding of von Willebrand’s factor to platelets and inhibits ristocetin-induced platelet agglutination. Platelet aggregation induced by type I collagen and Platelet Activating Factor (PAF) is also inhibited. The SZ2 antibody immunoprecipitates the components of the GPIb complex. It may also be used in Western Blot. |
