The CD35 antigen is a polymorphic molecule. Different molecular weights: 160, 190, 220, 250 and 285 kDa were reported for the various allotypes. It is known as the Complement Receptor type I (CR1) with affinity for C3b, C4b and iC3b. The CD35 antigen is expressed by granulocytes (except basophils), B lymphocytes, monocytes, some NK cells and erythrocytes. The CD35 antigen mediates phagocytosis of complement coated particles.
Технические характеристики
| Target Species | Human |
| Specificity | CD35 |
| Other Names | C3b/C4b receptor, CD35, complement receptor type 1, CR1 |
| Fluorochrome | UNLB |
| Regulatory Status | RUO |
| Size | 0.2 mg |
| Format | Freeze-dried |
| Clone | J3D3 |
| Isotype | IgG1 Mouse |
| Clone Description | The J3D3 monoclonal antibody inhibits CR1-mediated decay of cells bound to the alternative and classical pathways to C3-convertase sites. It also inhibits C3b dependent rosette formation with lymphocytes. |
