The CD28 antigen (Tp44) is a homodimer of disulfide-linked chains, with a molecular weight of 44 kDa each. CD28 antigen is expressed by a majority of CD3+ T lymphocytes. CD4+ T lymphocytes express the CD28 antigen more frequently than do CD8+ T lymphocytes. CD28 antigen is also present on plasma cells and thymocytes. This antigen is involved in the adhesion of T lymphocytes with B lymphocytes, through the B7/BB-1 (CD80) or B70/B7-2 (CD86) glycoproteins and provides a major co-stimulatory signal for T cell activation.
Технические характеристики
| Target Species | Human |
| Specificity | CD28 |
| Other Names | CD28, CD80/CD86 Ligand, Tp44 |
| Fluorochrome | PC5.5 |
| Regulatory Status | ASR |
| Size | 0.5 mL |
| Format | Liquid |
| Flow Product Line | IOTest |
| Clone | CD28.2 |
| Isotype | IgG1 Mouse |
| Clone Description | The CD28.2 monoclonal antibody costimulates T cell proliferation and cytokine production in the presence of T cell activators (αCD3, PMA, SEB). It inhibits proliferation of CD4+ T lymphocytes. It cross-reacts with Rhesus monkey peripheral blood lymphocytes. |
