The CD25 antigen (IL-2Rα chain, Tac or p55) is a single-chain glycoprotein with a molecular weight of 55 kDa which is the low affinity receptor for IL-2 (IL-2Rα). In conjunction with CD122 (IL-2Rβ, p75) and CD132 (IL-2Rγ, p64), CD25 antigen forms the high-affinity IL-2R complex. CD25 antigen is found on activated T and B cells, on activated monocytes and macrophages, and on T cell clones. It is also expressed on NK cells enriched from peripheral blood lymphocytes by culturing in the presence of IL-2. It is absent from thymocytes and resting T and B lymphocytes.
Технические характеристики
| Target Species | Human |
| Specificity | CD25 |
| Other Names | CD25, IL-2 Receptor, IL-2R1, IL-2Rα, Interleukin (IL)-2 receptor a-chain, p55, TAC |
| Fluorochrome | PC5 |
| Regulatory Status | ASR |
| Size | 1 mL |
| Format | Liquid |
| Flow Product Line | IOTest |
| Clone | B1.49.9 |
| Isotype | IgG2a Mouse |
| Clone Description | The B1.49.9 monoclonal antibody does not block the binding of IL-2 to its receptor. |
| Cross Reactivity | Mink, Ovine, Squirrel Monkey |
