The CD244 antigen, also called 2B4, is a 38 kDa cell surface signal transduction molecule found on almost all human NK cells. It induces a granule independent killing mechanism by NK effector cells. It is also found on γδ TCR T cells and appoximately half of peripheral αβ TCR CD8+ T cells. It is not found on B or naïve CD8+ T cells. Upon activation, most CD8+ T cells become CD244-positive. However, a small but significant minority of CD8+ T cells remain CD244-negative. This subset is associated with lower cytotoxic activity, lower γ-IFN production and higher IL-4 and IL-10 production. CD244 is a high affinity receptor for CD48.
Технические характеристики
| Target Species | Human |
| Specificity | CD244 |
| Other Names | 2B4, C1.7, CD244, p38 |
| Fluorochrome | PC5.5 |
| Regulatory Status | ASR |
| Size | 0.5 mL |
| Format | Liquid |
| Flow Product Line | IOTest |
| Clone | C1.7 |
| Isotype | IgG1 Mouse |
