The CD235a antigen, also called Glycophorin A, is a transmembrane, single-pass glycoprotein that contains carbohydrate, mostly in the form of sialic acid. CD235a has a molecular weight of 10 kDa. It is expressed by erythroid precursors and erythrocytes. Glycophorins A carries the antigen determinants for the MNS blood groups and has been proposed to be an inhibitor of hemagglutination and hemolysis. Glycophorin A binds siglec 5, and may also serves as receptor for cytokines and pathogens, including the malaria parasite, Plasmodium falciparum and some viruses, including influenza virus and hepatitis A virus.
Технические характеристики
| Target Species | Human |
| Specificity | CD235a |
| Other Names | CD235a, Glycophorin A |
| Fluorochrome | APC-Alexa Fluor* 750 |
| Regulatory Status | ASR |
| Size | 0.5 mL |
| Format | Liquid |
| Flow Product Line | IOTest |
| Clone | 11E4B-7-6 (KC16) |
| Isotype | IgG1 Mouse |
| Clone Description | The 11E4B-7-6 (KC16) antibody binds to the amino acid sequence 27-39 of glycophorin A and has no reactivity to glycophorin B. It reacts with immature erythrocytes including erythroblasts, proerythroblasts and reticulocytes. |
