The CD22 antigen (BL-CAM) is a transmembrane glycoprotein of the immunoglobulin superfamily. It may be expressed as two different isoforms: the α form (130 kDa) and the β form (140 kDa). CD22 antigen is a B cell restricted antigen expressed in the cytoplasm of B cell progenitors and on the surface of mature B lymphocytes. CD22 expression is lost after B-cell activation, prior to the plasma cell stage. It is absent from peripheral blood T lymphocytes, granulocytes, monocytes.
Технические характеристики
| Target Species | Human |
| Specificity | CD22 |
| Other Names | Bgp135, BL-CAM, CD22, Siglec2 |
| Fluorochrome | RD1 |
| Regulatory Status | ASR |
| Size | 0.5 mL |
| Format | Liquid |
| Flow Product Line | cyto-stat |
| Clone | HD239 |
| Isotype | IgG2b Mouse |
| Clone Description | The B3 antibody binds to an epitope located within the first Ig-like domain of CD22 antigen. It can be used to detect intracytoplasmic CD22 in flow cytometry after permeabilization. |
