The CD16 antigen is the low-affinity receptor for IgG (FcγRIII). The CD16 antigen exists in two different forms encoded by two different genes: FcγRIIIA (or III-2) and FcγRIIIB (or III-1). The genetic heterogeneity of CD16 generates alternative membrane-anchored molecules. One is a transmembrane form (FcγRIIIA, 50-65 kDa) expressed on NK cells, monocytes and macrophages. The other is a glycosylphosphatidylinositol (GPI)-anchored form (FcγRIIIB, 48 kDa) only expressed on neutrophils. It has been shown that the CD16 antigen can be non-covalently associated within the membrane of NK cells, to a disulfide-linked homo or heterodimer made from the 16 kDa CD3ζ chain and the FcεRIγchain.
Технические характеристики
| Target Species | Human |
| Specificity | CD16 |
| Other Names | CD16, Fc gamma R IIIa&b, FCγRIII, FcγRIIIA/IIIB |
| Fluorochrome | FITC |
| Regulatory Status | ASR, Japan IVD |
| Size | 0.5 mL |
| Format | Liquid |
| Flow Product Line | cyto-stat |
| Clone | 3G8 |
| Isotype | IgG1 Mouse |
| Clone Description | The 3G8 monoclonal antibody is inappropriate for western Blot use. 3G8 binds to both isoforms of the CD16 molecule. |
| Cross Reactivity | Cynomolgus Monkey, Hamadyras Baboon, Indian Rhesus, Olive Baboon, Capuchin Monkey, Common Marmoset, Squirrel Monkey, Equine, Canine |
