CD141, also known as thrombomodulin (TM) and BDCA-3, is an endothelial cell surface receptor. It is a 75 kD type I membrane glycoprotein and members of C-type lectin family. Two major isoforms exist, differentiated by the presence or not of sulfated glycosaminoglycan at Ser/Thr region. CD141 antigen is expressed on neutrophils, monocytes, platelets, a subpopulation of myeloid dendritic cells, vascular endothelial cells, and keratinocytes. It is a cofactor in the activation of protein C and initiation of the protein C anticoagulant pathway by binding to its ligand thrombin.
Технические характеристики
| Target Species | Human |
| Specificity | CD141 |
| Other Names | BDCA-3, CD141, Thrombomodulin |
| Fluorochrome | FITC |
| Regulatory Status | ASR |
| Size | 1 mL |
| Format | Liquid |
| Flow Product Line | IOTest |
| Clone | M80 |
| Isotype | IgG1 Mouse |
