The CD117 antigen is the 145 kDa protooncogene c-kit. It belongs to the class III receptor tyrosine kinase family. This antigen is the receptor for the stem-cell factor (SCF) encoded by the steel locus (Steel Locus Factor «SLF»). The CD117 antigen is expressed on very few normal bone marrow cells. The majority of CD117+ marrow cells co-express CD34. CD117 is also expressed on mast cells.
Технические характеристики
| Target Species | Human |
| Specificity | CD117 |
| Other Names | CD117, c-kit, SCF receptor, SCFR, stem cell factor receptor |
| Fluorochrome | PC5 |
| Regulatory Status | ASR |
| Size | 1 mL |
| Format | Liquid |
| Flow Product Line | IOTest |
| Clone | 95C3 |
| Isotype | IgG1 Mouse |
| Clone Description | The 95C3 antibody reacts with BFU-E, CFU-GEMM, CFU-GM and CFU-G. The 95C3 antibody reduces the binding of SCF to its receptor to about half of the maximum value. |
