Product Description Belonging to the Architect family of Chemistry and Immunoassay systems, the Abbott Architect i2000 is a reputable and high quality Japanese designed and manufactured Chemistry Analyzer testing over 55 assays with a maximum throughput of 200 tests per hour. The system is partially an open reagent system. Immunodiagnostic testing analyzes reactions between antigens and antibodies in response to infectious disease, autoimmune disorders, immune allergies and neoplastic disease. Antigens are foreign substances which enter a patients body and engage the immune system to respond. These substances most typically include toxins, tumors or microorganisms such as bacteria, virus, parasite or fungi. Antibodies are proteins produced by the bodys immune system in response to an antigen. The antigen-antibody response is the natural defense against invading organisms. Most immunochemistry systems use fluorescence as its operation principle. Fluorescence is the emission of electromagnetic radiation by a substance at one wavelength after it has absorbed energy at another wavelength. This reaction takes place in the Luminometer portion of the analyzer. The 2 main methods are referred to as Fluorescence Polarization Immunoassay (FPIA) and Chemiluminescence Immunoassay (CLIA). Nephelometry and Enzyme based immunoassay are less common methods used in immunochemistry analysis. Some of the enzyme methods are referred to as: Enzyme Immunoassay (EIA), Microparticle Enzyme Immunoassay (MEIA) and Enzyme Linked Immunosorbent Assay (ELISA). Immunodiagnostic studies are divided into two primary categories. Analysis of infectious disease are referred to as serological testing while assessment of the patients immune system is referred to as immune dysfunctional analysis. Some immunology instrumentation may include testing of routine chemistries or therapeutic drugs for consolidated testing. Serologic tests are classified in 4 main groups as listed. The most common tests within these groups are listed: Bacterial Tests Syphilis, Lyme, Legionnaire, Chlamydia, Streptococcal Viral Tests Mononucleosis, Epstein Barr, Rubella, Hepatitis, Rabies, HIV, Aids, Herpes Fungal Tests Histoplasmosis, Blastomycosis, Candida, Aspergillus, Cryptococcus Parasitic Tests Toxoplasmosis, Amebiasis Tests for Immune Dysfunction are used to diagnose inflammatory states, neoplastic states, nephtoric syndromes, liver disease and immune dysfunctions leading to typically, cancer. The most common tests for dysfunction are: Quantitative Immunoglobulins (IgA, IgG, IgM) Cryoglobulin Tests Collagen, Rheumatic and Connective Tissue Disease Tests Complement Components (C3,C4,C1) Antinuclear Antibody (ANA) Antiscleroderma (SCl-70) Antibody Test Total Hemolytic Complement (CH50) Anti-Smooth Muscle Antibody (ASMA) Test Antimitochondrial Antibody (AMA) Test Antiparietal Cell Antibody (APCA) Test IgE Antibody Cardiolipin Antibodies Cytoplasmic Neutrophil Antibodies (ANCA) Antisperm Antibody Test Alzheimers Disease Markers Tumor Markers 1 year warranty included Specifications Auto Sample Handling: Yes CLIA Complexity: Moderate Configuration: Floor Model Depth: 112 cm (44 in) Depth: 53 cm (21 in) Direct Sample (STAT): Yes Height: 122 cm (48 in) Height: 56 cm (22 in) Manufacturer: Abbott Diagnostics Maximum Throughput: 200 tests/hour Number of Assays: 23 On-Board Refrigeration: Yes Optical System: Luminometer Patient Sample Capacity: 135 Point Of Care: No Power Supply: 220V Reagent Capacity: 25 Reagent System: Closed Reagent Type: Liquid Sample Cycle Time: 1740 (sec) Sample Input Closed Tube: No Sample Input Type: Sample Tubes Sample Cups Sample Size Max: 150 &mu,L Sample Size Min: 15 &mu,L Sample Types: Plasma, Urine, Whole Blood, Serum Series: Architect Standby Mode: Yes Test Method: Chemiluminescence Detection Technology (CMIA) Unit #2 System Control System (SCC) Weight: 499 kg (1098 lb) Weight: 25 kg (55 lb) Width: 173 cm (68 in) Width: 39 cm (15 in)